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博金冠娱乐城备用网址:Route of Administration

博金冠平台是否已经被警方打击 www.ofvo6.com.cn SEPPIC offers excipients for the different routes of administration

Pharmaceutical drugs are developed for 3 main routes of administration: oral, injectable and topical routes. Oral route accounts for the majority of the pharmaceutical market, followed by injectable and then topical drugs. Each route of administration has its own advantages and disadvantages, as well as specific requirements.

Oral route

The oral route presents major benefits such as the ease of use (like tablets & capsules). These forms are usually cost efficient and can be used to formulate modified release systems which can improve bioavailability. Improving drug performance and safety is key for oral route.

SEPPIC designs and manufactures a wide range of excipients such as coatings, binders, fillers, disintegrants, solubilizers, emulsifiers, dedicated to oral applications.

Whatever oral forms developped (tablets, capsules, powder, syrups, gels…), formulators may use one or several SEPPIC excipients to improve bioavailability, stability, delivery, taste masking, compliance.

SEPPIC pays a great attention to offer ready-to-use excipients with the highest grade of quality and follows the IPEC-GMP standards for all its excipients dedicated to oral route. SEPPIC was a pioneer in the EXCiPACT? standard certification and has been successfully audited and certified since 2013.

Injectable route

The injectable route is used for a quick administration (adapted to emergencies), a controlled dosage, the absence of intestinal and hepatic first pass effect and continuous medication (infusion). This route of administration is growing with the developments of biological drugs posing new challenges.

SEPPIC designs and manufactures adjuvants for therapeutic vaccines and excipients such as solubilizers and emulsifiers dedicated to injectable route of administration.

Whatever injectable drugs developed - biologicals or small molecules - and whatever the parenteral administration - intravenous, subcutaneous, ocular - drugs can be developed with one or several SEPPIC products to improve solubility, stability, safety and efficiency of pharmaceutical actives.

SEPPIC excipients are manufactured with the same high quality standards as for active pharmaceutical ingredients. Injectable excipients comply with the GMP Part II guidelines and current pharmacopoeias. Adjuvants dedicated to therapeutic vaccines are manufactured under aseptic conditions in a pharmaceutical facility and comply with GMP Part I guidelines.

Topical route

The topical route is easy to use for patients. It can also be used for a local effect and has no first pass effect, which can be of great benefit in reducing side effects of oral dosage forms. Challenges of this route of administration are linked to the texture of the drug to improve patient compliance as well as efficacy.

SEPPIC designs and manufactures excipients such as emulsifiers, solubilizers and texturing agents for the topical route of administration to help formulators optimize and simplify their formulations.

There is a wide range of topical forms. The most common ones are gels and creams but other formulas exist and can be excellent drug vehicles: foams, spray, patches, cream gels.

The main challenges for formulating topical forms are Active Pharmaceutical Ingredient (API) solubility, stability of the formulation, penetration of the API, formulation of a combination of APIs, patient compliance.

Topical excipients follow GMP-IPEC guidelines and are EXCiPACT? certified.

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