Skip to main content

博金冠是什么:Solubility Enhancement and Emulsion Formulation

博金冠平台是否已经被警方打击 www.ofvo6.com.cn SEPPIC adresses formulator issues with solubilizers and emulsifiers

Drug formulators often face API (Active Pharmaceutical Ingredient) bioavailability issues
Solubility is one of the key factors. A rising number of therapeutic drugs currently in preclinical and clinical developments are poorly water soluble. This number is estimated at 40-70% of NCEs (New Chemical Entities (NCEs)).

Once administered, a drug must be in a solution form to be absorbed regardless of the route of administration.

Developing pharmaceutical formulations with appropriate solubility will be one of the key challenges of next years.

When solution is not the optimal option to deliver the API or when drug formulators want to develop a modified release system, they might go through emulsion vehicles thanks to use of emulsifiers.

Emulsifiers and solubilizers offered by SEPPIC enable drug formulators to manage their challenges with poorly water soluble APIs.

Solubilization

Whatever the route of administration of a drug, the formulator might have the need of a solubilizer from SEPPIC to achieve optimal solubilization.
The target is to achieve a concentrated, clear, homogenous and stable solution in order to deliver the API in an efficient way.

SEPPIC offers different ranges of solubilizers under:

  • ?MONTANOX? range: Polysorbates
  • ?SEPITRAP? range: Solubilizers in powder form for direct compression
  • ?SEPICLEAR? : The SEPPIC novel excipient
  • ?SIMULSOL?: Fatty acids, fatty alcohols and castor oil derivatives


The choice of solubilizers is mainly driven by route of administration and nature of the API.

Emulsion

Drugs may be formulated with an emulsion as a vehicle to improve its bioavailability (sustained release, lipophilic or hydrophilic API solubilization, permeability...) or treatment compliance (texture).
An emulsion is a system made of at least two phases. It should be homogeneous and stable, thanks to addition of one or several emulsifiers.
Emulsifiers are used in pharmaceutical formulations to get stable emulsions to achieve the physico-chemical characteristics required for optimal delivery of API.

Depending on the emulsion type - Water in oil (W/O) or Oil in water (O/W) - emulsifiers are selected depending on their lipophilic/hydrophilic nature. They can be characterized thanks to their HLB (Hydrophilic/Lipophilic Balance) value.

SEPPIC offers different ranges of emulsifiers:

  • ?MONTANE? range: sorbitan esters
  • ?MONTANOX? range: polysorbates
  • ?SIMULSOL? range: ethoxylated fatty acids, fatty alcohols and castor oils
  • ?SIMALINE WO? : PEG 30 Dipolyhydroxystearate


Some emulsifiers may also have other functions depending on their HLB value: anti-foaming, wetting, foaming or solubilising functions.
?

  • 外媒称中俄元首达成重要共识 两国合作达到历史最高水平 2019-02-23
  • 永济“审理轮训”有力提升执纪执法水平 2019-02-23
  • 哪个不在痛打落水狗呢 2019-02-22
  • 深化对经济工作主线的认识 从供需关系看供给侧结构性改革 2019-02-21
  • 联播快讯:尘暴席卷火星  “机遇”号休眠失联 2019-02-20
  • 端午节赛龙舟!这样的龙舟比赛你见过吗? 2019-02-19
  • 全球都在抛售美债,俄罗斯单月卖掉一半 2019-02-19
  • 10名藏医学子首次被授予临床医学硕士学位 2019-02-18
  • 大力弘扬革命传统传承红色基因 持续深化作风建设造福老区人民 2019-02-17
  • 发挥自身优势 奋力走在前列——习近平总书记在山东考察回访记 2019-02-17
  • 简直不要命!男子开车窗偷摸狮子遭狂吼吓破胆 2019-02-16
  • 一个理想的数列递减,看着就想笑,根本放不出什么屁来 2019-02-16
  • 【记者直击】花莲地震已确认有两名失踪人员被困同一地点 2019-02-15
  • 【家国网聚·网络旺年】把春节慰问效益做大,让旺年过得更旺 2019-02-15
  • 组图:高考迎来“00后” 北京6万余名考生走进考场 2019-02-14
  • 928| 501| 870| 186| 423| 153| 167| 101| 918| 686|